Lymphoma of the uterine cervix – a rare clinical presentation

Dušica Petrović Rodić; Tatjana Kastratović; Danijela  Jovanović; Vladan Marković; Jasmina Stojanović; Dalibor Jovanović

doi:10.2298/VSP210707080P

Vol. 79 Br. 12 (2022)

Limfom grlića materice – retka klinička prezentacija

DOI: 10.2298/VSP210707080P

Dušica Petrović Rodić⁺⁻
Tatjana Kastratović⁺⁻
Danijela Jovanović⁺⁻
Vladan Marković⁺⁻
Jasmina Stojanović⁺⁻
Dalibor Jovanović⁺⁻

Dušica Petrović Rodić

University of Kragujevac, Faculty of Medical Sciences, Department of Pathology, Kragujevac, Serbia

Tatjana Kastratović

University Medical Center Kragujevac, Department of Gynecology and Obstetrics, Kragujevac, Serbia

Danijela Jovanović

University of Kragujevac, Faculty of Medical Sciences, Department of Internal Medicine, Kragujevac, Serbia

Vladan Marković

University of Kragujevac, Faculty of Medical Sciences, Department of Radiology, Kragujevac, Serbia

Jasmina Stojanović

University of Kragujevac, Faculty of Medical Sciences, Department of Otorhinolaryngology, Kragujevac, Serbia

Dalibor Jovanović

University of Kragujevac, Faculty of Medical Sciences, Department of Pathology, Kragujevac, Serbia

PDF (engleski)

Objavljeno

2023-01-04

Sekcija

Prikaz bolesnika

Kako citirati

1.

Petrović Rodić D, Kastratović T, Jovanović D, Marković V, Stojanović J, Jovanović D. Limfom grlića materice – retka klinička prezentacija. Vojnosanit Pregl [Internet]. 04. Januar 2023. [citirano 12. Juli 2026.];79(12). Dostupno na: https://asistent.ceon.rs/index.php/vsp/article/view/33044

Sažetak

Uvod. Limfomi su maligne bolesti limfocitne loze. Postoje dva osnovna tipa limfoma: Hodgkin-ov limfom (HL), čija je osnovna karakteristika prisustvo Reed-Sternberg-ovih ćelija, i non-Hodgkin-ov limfom (NHL), koji predstavlja heterogenu grupu bolesti, a u zavisnosti od brzine rasta i toka bolesti mogu biti indolentni (spororastući tok) i agresivni (brzorastući tok). Folikularni limfom (FL) najčešći je indolentni oblik NHL, dok je difuzni krupnoćelijski B‑limfom (diffuse large b-cell lymphoma, DLBCL) najčešći agresivni oblik. Prikaz bolesnika. U radu je prikazana bolesnica stara 35 godina sa NHL, DLBCL, lokalizovanim u grliću materice, kojoj je nakon biopsije grlića materice, patohistološki dijagnostikovana displazija lakog stepena (CIN1/L-SIL) pokrovnog epitela grlića materice, a zatim dokazana infekcija humanim papiloma virusom (HPV), podtipovima 16 i 31. Dijagnoza DLBCL je patohistološki potvrđena na koničnom isečku vaginalne porcije uterusa, nakon čega je bolesnica lečena sa osam ciklusa hemioterapije po protokolu RCHOP. Zaključak. Koegzistencija CIN1/L-SIL i NHL je slučajna. Usled toga, može se prevideti prateći cervikalni limfom, koji je uobičajeno lokalizovan subepitelno, ukoliko se biopsije ne uzimaju na adekvatan način i ukoliko se ne uradi HPV serotipizacija uzorka biopsije.

Ključne reči

biopsija
limfom, nehodžkinov
papillomaviridae
serotipizacija
grlić materice, displazija

DOI: 10.2298/VSP210707080P

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