Medicinski časopis
type: channel
publisher: Serbian Medical Society - Section Kragujevac, Kragujevac
language: en
publication name: Medicinski časopis
issn: 0350-1221
items: DOES ZAMZAM WATER HAVE ONCOLYTIC EFFECTS?
items: Persistent pulmonary hypertension in a neonate with Vein of Galen malformation
items: DOCTOR ĐORĐE JOANOVIĆ, THE FATHER OF SERBIAN ONCOLOGY
items: Surgical Treatment of Hyperthyroidism – Experience of the Department of Endocrine Surgery, University Clinical Center Kragujevac
items: FIBRINOLYSIS DISORDERS IN SEPSIS: THE IMPORTANCE OF EARLY DETECTION OF ABNORMALITIES IN SEPSIS-INDUCED COAGULOPATHY AND AVAILABLE LABORATORY MARKERS OF FIBRINOLYSIS
items: Oral helth behaviors, awareness, and knowledge among undergraduate students at the Faculty of Medicine in Bosnia and Herzegovina: A cross-sectional studya
items: AWARENESS AND ATTITUDES OF PRIMARY HEALTHCARE PHARMACISTS REGARDING THE EFFICACY AND SIGNIFICANCE OF STEM CELL APPLICATIONS FOR MEDICAL PURPOSES-Qualitative prospective study
items: SHORT-TERM OUTCOMES OF LAPAROSCOPIC COLORECTAL RESECTIONS FOR CANCER: A FIVE-YEAR SINGLE-CENTRE EXPERIENCE FROM SERBIA
items: THE ROLE OF ARTIFICIAL INTELLIGENCE IN GENERAL PRACTICE - CHALLENGES AND POTENTIAL RISKS
items: ACUTE CHOLECYSTITIS CAUSED BY GRANULOMATOSIS WITH POLYANGIITIS - A RARE CASE
items: PHONOLOGICAL AWARENESS IN PRESCHOOL CHILDREN WITH DEVELOPMENTAL LANGUAGE DISORDER
items: FORENSIC CHARACTERISTICS OF ROAD TRAFFIC ACCIDENTS - А SECULAR TREND STUDY
items: Leiomyoma in the Douglas' pouch
items: The role of neurotrophins in acute coronary syndrome prognostic and diagnostic value of new biomarkers
items: Assessment of indicators of children education in Serbia with implication to the health literacy
items: Impact of anxIety on self-perceIved oral health among medIcal students
items: Effects of bile salts and hymecromone on gallstone recurrence in adult patients after laparoscopic cholecystolithotomy
items: CALCITONIN NEGATIVE MEDULLARY THYROID CARCINOMA
items: PSYCHODERMATOLOGY – FOCUS ON PSYCHIATRIC OUTCOMES OF THERMAL SKIN INJURIES
items: Kawasaki disease - a single centre experience
items: The Role of the Neutrophil-to-Lymphocyte Ratio in the Development of Heart Failure in Patients with Concomitant Hypertension, Type 2 Diabetes, and Obesity
items: A brief screening instrument for the early identification of autism spectrum disorders in Serbia: A psychometric study of the Minute for autism (MAUT) instrument
items: The role of tryptase in the human body: From normal to pathology
items: Spontaneous subcapsular renal hematoma as a cause of acute abdominal pain - a case report
items: WORK STRESS, BURN-OUT SYNDROME AND PSYCHOLOGICAL CONSEQUENCES
items: THE IMPAKT OF DOMINANT CENTRAL NERVOUS SYSTEM INJURIES ON THE SURVIVAL OF TRAFFIC ACCIDENT VITIMS IN MONTENEGRO
items: Can leukotriene receptors inhibitors preserve cognitive functions in asthma patients?
items: SUCCESSFUL CARDIOPULMONARY RESUSCITATION USING A DEFIBRILLATOR PLACED IN A PUBLIC PLACE - CASE REPORT
items: PREHOSPITAL CARE AND TREATMENT OF INJURED IN TRAFFIC ACCIDENTS
items: RESILIENCE AND HEALTHY LIFESTYLES IN THE POPULATION OF NURSES, NURSING STUDENTS AND ADMINISTRATIVE WORKERS

DOES ZAMZAM WATER HAVE ONCOLYTIC EFFECTS?
type: item
description: Nil
subject: Commentary
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subject: Array
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creator: Huseyin Caksen
rights: Copyright (c) 2026 Medicinski časopis
date: 2026-05-11
publication date: 2026-05-11
doi: 10.5937/mckg60-63392

Persistent pulmonary hypertension in a neonate with Vein of Galen malformation
type: item
description: The vein of Galen malformation (VGAM) is a rare congenital vascular malformation. However, in 40-50% of cases, it can present in the newborn period as high-output congestive heart failure and rarely as neonatal persistent pulmonary hypertension (PPHN). We present the case of a female neonate born at 31 weeks' gestation via urgent cesarean section. As the newborn was premature with signs of respiratory distress, it was admitted to our hospital’s neonatal intensive care in the 14th hour of life. On the 8th day of life, a cardiac murmur was noted, and a cardiology consultation was obtained. Echocardiography was performed to exclude critical congenital heart disease, but rather showed existing persistent pulmonary hypertension of the newborn (PPHN) with near systemic pulmonary pressures. The patient was started on sildenafil and a low-dose diuretic. Initially, there was an overall improvement in the child's general condition. However, the patient deteriorated on 15th day of life. Repeat echocardiography revealed suprasystemic PPHN, with global ventricular dysfunction, and ductal flow reversal was noted at the level of the aortic isthmus and right-to-left shunting at the atrial level. Anticongestive medications (ACE inhibitor, diuretics) were given in addition to sildenafil. Cranial ultrasound was ordered, and the scan revealed a midline cystic formation measuring 13.7 x 13.2 mm with color Doppler showing turbulent blood flow in the vein of Galen area, which was diagnostic for vein of Galen malformation. Treatment of our patient included mechanical ventilation and other supportive measures, treatment of congestive heart failure, and PPHN. However, the neonate remained in critical condition, and even though endovascular embolization was considered, transfer to a neurosurgical center was impossible, and the baby succumbed to her disease. Even though the association of VGAM with PPHN of the newborn is not common, in cases of systemic PPHN and congestive heart failure refrac…
subject: Review
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subject: Array
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creator: Karin Vasic
creator: Jelena Vucic
creator: Misel Mutlag
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-12-21
publication date: 2025-12-21
doi: 10.5937/mckg60-60599

DOCTOR ĐORĐE JOANOVIĆ, THE FATHER OF SERBIAN ONCOLOGY
type: item
description: Đorđe Joanović was born in Vienna on June 16, 1871, to mother Marija Joanović, born Vlahović, and father Harinton Joanović. The Joanović family originates from the village of Beodre. He left his Viennese university career, scientific works and famous Viennese laboratories and came to Belgrade after the end of the First World War with a great desire as a patriot to help Serbia. Doctor Đorđe Joanović was an innovative scientist, a pioneer in the field of laboratory study of oncological diseases and the epidemiology of carcinogenesis, and in that field he was world-renowned and respected. Doctor Joanović is one of the founders of the Faculty of Medicine in Belgrade. He initiated the establishment of the then most modern Institute of Pathology in Belgrade. Doctor Joanović founded and became the first president of the Yugoslav Society for the Study and Suppression of Cancer. He was elected four times as the dean of the Faculty of Medicine in Belgrade. Professor Đorđe Joanović was a respected member of Matica Srpska in Novi Sad and a senior scientific associate of the Serbian Academy of Sciences. He was elected an honorary member of the German and Czech Oncological Committee for the Suppression of cancer. He was the permanent representative of the Kingdom of Yugoslavia in Paris at the International Office for Public Hygiene. He was elected president of the Yugoslav and Serbian Medical Association, as well as the representative of the Kingdom of Yugoslavia in the All-Slovenian Medical Association. Doctor Đorđe was also a member of the Medical Council of the Army of the Kingdom of Yugoslavia, as well as a professor of Military Health. Professor Joanović was a member of the Committee of the International Institute for Geographical Pathology. He became the founder and president of the Fund for Helping Poor Students. He was also the editor of the Serbian Archive for All Medicine, as well as a member and correspondent of numerous editorial offices of medical journals. The Insti…
subject: Historical Item
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subject: Array
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creator: DIJANA PILJIĆ
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-11-27
publication date: 2025-11-27
doi: 10.5937/mckg60-56891

Surgical Treatment of Hyperthyroidism – Experience of the Department of Endocrine Surgery, University Clinical Center Kragujevac
type: item
description: Introduction: Hyperthyroidism represents a significant endocrine disorder, with the most common causes being Graves’ disease (GD), toxic multinodular goiter (TMNG), and toxic adenoma (TA). Surgical treatment occupies an important place in the therapeutic algorithm, particularly in situations where medical therapy or radioactive iodine treatment is contraindicated or ineffective. Objective: To present the experience of the Department of Endocrine Surgery of the University Clinical Center Kragujevac in the surgical treatment of hyperthyroidism during the period 2018–2024. Materials and Methods: A retrospective analysis was conducted of 188 patients operated on for hyperthyroidism, out of a total of 480 patients who underwent surgery for thyroid diseases over a six-year period. The analyzed parameters included diagnosis type, type of surgical procedure, demographic data, incidence of carcinoma on definitive histopathological findings, and postoperative complications. Results: Among the 188 operated patients, 62 had GD, 65 had TMNG, and 61 had TA. In patients with GD, total thyroidectomy was performed in 55 cases and near-total thyroidectomy in 7 cases. In the TMNG group, total thyroidectomy was performed in 60 patients and near-total thyroidectomy in 5 patients. In all 61 patients with TA, lobectomy was performed. The mean age was 48.6 years for GD, 58.3 years for TMNG, and 46.5 years for TA. The female-to-male ratio was 5:1 in GD, 4:1 in TMNG, and 4:1 in TA. Thyroid micropapillary carcinoma was detected in 1 patient with GD, 5 patients with TMNG, and 2 patients with TA. Complications included seroma in 8 patients, hematoma in 4 patients, permanent recurrent laryngeal nerve paralysis in 2 patients, transient recurrent laryngeal nerve paralysis in 5 patients, and transient hypocalcemia in 14 patients. Conclusion: Surgical treatment of hyperthyroidism in our center has demonstrated favorable outcomes with a low rate of serious complications. The results are consistent wi…
subject: Original Scientific Paper
  topic: section
subject: Array
  topic: keywords
creator: Slobodan Jakovljevic
creator: Jovan Pešović
creator: Duško Nešovanović
creator: Vladimir Tvrdišić
creator: Marko
creator: Borka Milev
creator: Zlata Juković
rights: Copyright (c) 2026 Medicinski časopis
date: 2026-03-18
publication date: 2026-03-18
doi: 10.5937/mckg60-64223

FIBRINOLYSIS DISORDERS IN SEPSIS: THE IMPORTANCE OF EARLY DETECTION OF ABNORMALITIES IN SEPSIS-INDUCED COAGULOPATHY AND AVAILABLE LABORATORY MARKERS OF FIBRINOLYSIS
type: item
description: Sepsis is a life-threatening organ dysfunction caused by an ineffective host response to infection. Some of the most prevalent disorders in sepsis are hemostatic disorders. Sepsis often develops a state of impaired anticoagulant activity and fibrinolysis suppression, called sepsis-induced coagulopathy. Damage to the fibrinolytic system is increasingly considered a key factor in sepsis-induced coagulopathy. Impaired fibrinolysis in sepsis can contribute to undesirable outcomes such as microvascular thrombosis, organ dysfunction, and increased mortality. Given that one of the postulates related to sepsis is that prompt diagnosis and quick care are necessary, it would be of great importance to diagnose various forms of coagulopathies in sepsis at the beginning of their occurrence, for an adequate therapeutic approach. In this sense, easily accessible, routine diagnostic tests are necessary. Conventional laboratory tests for coagulopathies so far fail to fully define sepsis-induced coagulopathy. Particularly challenging is the testing of hypofibrinolysis in routine practice. The objectives of our study were to review the available scientific literature to investigate the relationship between inflammation and coagulation in sepsis, fibrinolysis disorders in sepsis-induced coagulopathy, to determine the importance of early recognition of these disorders in sepsis, and to investigate the available laboratory markers of fibrinolysis and coagulopathies. Key words: sepsis-induced coagulopathy; fibrinolysis; fibrinolysis damage; viscoelastic tests.
subject: Review Paper
  topic: section
subject: Array
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creator: Marija Simonovic
creator: Marijana Stanojevic Pirkovic
creator: Jelena Mijailovic
creator: Danijela Jovanovic
creator: Marija Vraneš
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-11-13
publication date: 2025-11-13
doi: 10.5937/mckg60-60288

Oral helth behaviors, awareness, and knowledge among undergraduate students at the Faculty of Medicine in Bosnia and Herzegovina: A cross-sectional studya
type: item
description: Introduction: The aim of this study was to assess oral hygiene habits, as well as awareness and knowledge among undergraduate students at a Faculty of Medicine in Bosnia and Herzegovina. Methods: This cross-sectional study was conducted at the Faculty of Medicine in Foča and included 333 students across three study programs: Medicine (M), Nursing (N), and Special Education and Rehabilitation (SER). The questionnaire was used to obtain demographic information, as well as data on oral hygiene habits and knowledge of oral health. Results: The largest proportion of students (56.2%) brush their teeth twice daily. A higher percentage of N and SER students brush their teeth longer than M students (p=0.004). Students most often replace their toothbrushes every 3 months or sooner (76.3%); 58.9% regularly visit a dentist; and 61% report no oral health problems. Only 14.4% of students believe that dental plaque dysbiosis is the cause of caries, while more than half of the students (53.5%) do not know the impact of dental plaque. Additionally, more than one-third of students (35.7%) are unaware of preventive measures for oral disease. A greater number of M and N students than SER students reported that oral health is related to cardiovascular disease (p=0.002), and more M students reported that it is related to cancer compared to SER students (p=0.032). Conclusion: The results of this study indicate limited knowledge of oral health among students across all three study programs, underscoring the need to improve oral health education for health sciences students.oralno-higijenske navike, oralno zdravlje, dentalni plak, mjere prevencije
subject: Original Scientific Paper
  topic: section
subject: Array
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creator: Ana Cicmil
creator: Smiljka Cicmil
creator: Jelena Lecic
creator: Olivera Govedarica
creator: Tanja Ivanovic
creator: Marija Lucic
creator: Ilija Joknic
creator: Jelena Krunic
rights: Copyright (c) 2026 Medicinski časopis
date: 2026-03-18
publication date: 2026-03-18
doi: 10.5937/mckg60-63675

AWARENESS AND ATTITUDES OF PRIMARY HEALTHCARE PHARMACISTS REGARDING THE EFFICACY AND SIGNIFICANCE OF STEM CELL APPLICATIONS FOR MEDICAL PURPOSES-Qualitative prospective study
type: item
description: Introduction: In recent years, interest in the collection and preservation of umbilical cord blood stem cells has increased substantially, owing to their therapeutic potential in a range of medical conditions. As highly accessible healthcare professionals, primary care pharmacists are frequently consulted on diverse medical issues. Consequently, it is imperative that they possess comprehensive knowledge—including a thorough understanding of stem cell applications—and engage in ongoing professional development. Objective: This study aimed to assess the awareness, attitudes, and opinions of licensed pharmacists working in primary healthcare regarding the medical use of stem cells. Methods: A cross-sectional survey was conducted using anonymous questionnaires distributed to pharmacists in primary healthcare settings across the Central part of Serbia. Data was collected from July 1 to August 1, 2022, and analyzed using IBM SPSS Statistics and MS Excel. Inclusion criteria encompassed current employment as a primary healthcare pharmacist in Serbia and voluntary informed consent to participate in the study. Results: A total of 248 pharmacists participated, the majority being female and employed in private healthcare institutions. The analysis revealed statistically significant differences in awareness, attitudes, or opinions between pharmacists working in the public and private sectors, except for a significant difference regarding knowledge of the existence of a stem cell donor registry (p<0.05). Conclusion: The findings indicate that pharmacists in both the public and private primary care sectors possess different levels of knowledge and share similar attitudes toward stem cell applications, with the promiment awereness of the pharmacist employed in private sector. The study highlights the critical importance of continuous education and training for pharmacists in the evolving field of regenerative medicine. Keywords: stem cells, regenerative medicine, pharmacists, attit…
subject: Original Scientific Paper
  topic: section
subject: Array
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creator: Tamara Nikolic Turnic
creator: Marija Aksentijevic
creator: Maria Mikerova
creator: Vladimir Reshetnikov
rights: Copyright (c) 2026 Medicinski časopis
date: 2026-03-13
publication date: 2026-03-13
doi: 10.5937/mckg60-63075

SHORT-TERM OUTCOMES OF LAPAROSCOPIC COLORECTAL RESECTIONS FOR CANCER: A FIVE-YEAR SINGLE-CENTRE EXPERIENCE FROM SERBIA
type: item
description: Objective: To evaluate the short-term outcomes of laparoscopic colorectal resections for colorectal cancer in a single Serbian tertiary centre. Methods: A retrospective cohort study included 97 patients who underwent elective laparoscopic colorectal resections between January 2018 and March 2023. Demographic, perioperative, and oncologic data were analyzed. Primary outcomes were 30-day morbidity and mortality; secondary outcomes included operative time, conversion, re-intervention, length of stay, and lymph-node yield. Logistic regression identified independent predictors of complications. Results: The cohort comprised 59 men (60.8%) and 38 women (39.2%), with a median age of 71 years. Conversion to open surgery occurred in 6 patients (6.1%), while re-intervention was required in 3 (3.1%). The median operative time was 120 minutes for colonic and 175 minutes for rectal resections. Median lymph-node yield was 15, with all achieving R0 resection. The overall 30-day morbidity rate was 17.5%, with no perioperative deaths. General complications occurred in 12.4% and surgery-specific complications in 11.3%, with partial overlap. Median length of stay was 9 days, significantly longer in men and diabetic patients. Logistic regression confirmed cardiomyopathy as an independent predictor of postoperative complications (OR 7.5, p = 0.008). Conclusion: Laparoscopic colorectal resections in this series were associated with acceptable morbidity, no mortality, low conversion, and adequate oncologic quality. Cardiomyopathy was identified as a major perioperative risk factor, highlighting the need for tailored perioperative management.
subject: Original Scientific Paper
  topic: section
subject: Array
  topic: keywords
creator: Boško Milev
creator: Saša Dragović
creator: Mihailo Bezmarević
creator: Miodrag Jocić
creator: Jovana Stevanović
creator: Ivan Pantić
creator: Miroslav Mitrović
creator: Srđan Petković
creator: Darko Mirković
creator: Irfan Ćorović
creator: Haris Plojović
creator: Filip
creator: Milan Jovanović
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-12-21
publication date: 2025-12-21
doi: 10.5937/mckg59-61537

THE ROLE OF ARTIFICIAL INTELLIGENCE IN GENERAL PRACTICE - CHALLENGES AND POTENTIAL RISKS
type: item
description: Artificial intelligence has a significant role in the field of primary health care and its application is becoming more common. Artificial intelligence helps doctors of general medicine on several levels, in high-quality diagnosis and therapy planning, and by processing a large amount of data, in providing more time for the implementation of sophisticated tasks. Despite its many advantages, it is believed that artificial intelligence can negatively affect the doctor-patient relationship. Artificial intelligence in general medicine represents a significant component in the further development of personalized medicine, individual approaches to treatment and quality health care for patients.
subject: Review Paper
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subject: Array
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creator: Suncica Stankov
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-06-05
publication date: 2025-06-05
doi: 10.5937/mckg59-56000

ACUTE CHOLECYSTITIS CAUSED BY GRANULOMATOSIS WITH POLYANGIITIS - A RARE CASE
type: item
description: The most commonly affected organs in Granulomatosis with polyangiitis (GPA) include kidneys and lungs, while presentation in other organ systems is rare. [1, 2, 3]. We hereby present a case of vasculitic changes in the gallbladder, as the initial manifestation of GPA. A 65-year-old woman presented with fever and generalized weakness and was admitted to hospital. Upon admission, physical examination revealed signs of dehydration, mild hypotension and tachycardia. There was no palpable tenderness in the abdomen, and Murphy’s sign was negative. Initial work-up revealed normocytic anemia, elevated markers of inflammation. Urinalysis revealed protein and red blood cells. Blood and urine cultures were negative, and no signs of inflammation were identified on radiographic imaging. Due to persisting fever and unresolved inflammatory process despite the usage of parenteral antibiotic treatment, a computed tomography (CT) was also performed and revealed calculous cholecystitis necessitating laparoscopic cholecystectomy. Histopathology of the resected gallbladder showed small-vessel vasculitis. Laboratory tests revealed positive proteinase-3-anti-neutrophil cytoplasmic antibodies (PR3-ANCA) with an onset of renal dysfunction. These results supported a diagnosis of granulomatosis with polyangiitis (GPA) and the patient was started with glucocorticoids and intravenous cyclophosphamide. After this treatment, the patient’s general condition stabilized, creatinine and C-reactive protein levels decreased, and anemia resolved as well. This case highlights the importance of considering vasculitis in patients with unexplained persistent fever and systemic symptoms, especially when common causes have been excluded.
subject: Review
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subject: Array
  topic: keywords
creator: Vanja Petković
creator: Sonja Golubović
creator: Tatjana Ilić
creator: Sandra Jelčić
creator: Zorana Ostojić
creator: Violeta Knežević
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-06-05
publication date: 2025-06-05
doi: 10.5937/mckg59-55630

PHONOLOGICAL AWARENESS IN PRESCHOOL CHILDREN WITH DEVELOPMENTAL LANGUAGE DISORDER
type: item
description: ABSTRACT Objectives. To determine the level of development of phonological awareness in children with developmental language disorder at the age of four to six years compared to children with typical language development. Methods. Ninety children aged 4 to 6, of both genders, divided into three groups, participated in the study. The Phonological Awareness Test was applied. The study was conducted during January and February 2024. Results. The analysis of the results showed that phonological awareness deficit was not more frequently manifested in children with developmental language disorder compared to children of typical development, as well as that there was no statistically significant difference in the manifestation of phonological awareness deficit in children with developmental language disorder in relation to gender, in terms that these problems are more frequently found in boys. Key words: developmental language disorder, phonological awareness, typical language development
subject: Original Scientific Paper
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subject: Array
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creator: Mira Jovanovska
creator: Vesna Lazarovska
creator: Mirna Zelić
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-11-17
publication date: 2025-11-17
doi: 10.5937/mckg59-57832

FORENSIC CHARACTERISTICS OF ROAD TRAFFIC ACCIDENTS - А SECULAR TREND STUDY
type: item
description: Objective: Оbjective of work is to determine the forensic characteristics of road traffic accidents in territory of Raška District for period from 2009 to 2024. Material and methodology: Observational, cross-sectional epidemiological study, in which a retrospective analysis of the characteristics of traffic accidents in Raška District of Republic of Serbia over past sixteen years was performed. Results: Total number of road traffic accidents in observed period was 18.092. The research analyzed data from 2.129 road traffic accident participants who had a positive blood alcohol concentration. Largest number of road traffic accidents occurred in city of Kraljevo, outside of a populated area. Largest percentage of participants were motor vehicle drivers (88.54%), male (93.2%), with an average age of around 40 years. Seasonal relationship was observed in occurrence of road traffic accidents (August, September), as well as a higher incidence on weekends. Participants who were in the stage of heavy drinking more often suffered serious bodily injury, while participants who were in a state of intoxication and light drinking more often suffered minor bodily injury. Conclusion: Road traffic accidents in the Raška District are the result of a combination of several factors, including driving under the influence of alcohol, traffic infrastructure, high population density in certain cities and specific characteristics of Ibar Highway.
subject: Original Scientific Paper
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subject: Array
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creator: Ivan Petrović
creator: Stevan Barać
creator: Filip
creator: Ksenija Bošnjaković
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-11-27
publication date: 2025-11-27
doi: 10.5937/mckg59-61801

Leiomyoma in the Douglas' pouch
type: item
description: Leiomyomas (myoma, fibromyoma or fibroid) are benign tumors of smooth muscle cells. They are predominantly localized in the body of the uterus, but they can also develop in the broad ligament, ovaries, cervix, Douglas space and round ligament. Their frequency ranges from 5.4 to 77%, depending on the population examined or the applied diagnostic technique. Most leiomyomas are asymptomatic, but can present with a wide range of symptoms. Treatment includes pharmacological treatment and surgical treatment. A patient with a leiomyoma of the Douglas space coexisted with leiomyomas of the uterine body. Apart from intense pain in the lower part of the stomach, she had no other symptoms. Abdominal ultrasound examination, transvaginal ultrasound examination and computer tomography revealed an enlarged, myomatous uterus and a tumoral change on the right ovary. In an extensive operation, the uterus and both fallopian tubes were removed. The final diagnosis of a tumor changes in Douglas' space, which was initially considered a potentially malignant tumor of the right ovary, was established by a pathohistological examination after the operation. Leiomyomas are relatively common benign tumors of the uterine body. Their early diagnosis during a gynecological examination enables timely treatment that avoids hysterectomy and maintains fertility. Leiomyomas of atypical localization have a low incidence and an unclear clinical picture, and their final diagnosis is predominantly made after surgery.
subject: Review
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subject: Array
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creator: Marijana C Jandrić-Kočić
creator: Snežana Knežević
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-06-05
publication date: 2025-06-05
doi: 10.5937/mckg59-53265

The role of neurotrophins in acute coronary syndrome prognostic and diagnostic value of new biomarkers
type: item
description: Acute coronary syndrome (ACS) remains a leading cause of morbidity and mortality worldwide. While existing diagnostic and prognostic biomarkers have improved patient care, there's still a need for newer, more specific markers to enable more precise risk stratification and individualized treatment. Neurotrophins are a family of proteins essential for neuronal survival and function. In recent years, their role in cardiovascular diseases has become increasingly recognized. The aim of this review is to present current knowledge on the role of neurotrophins, primarily BDNF and NGF, in the pathophysiology of ACS, and to evaluate their potential as novel diagnostic and prognostic biomarkers. Analyzed studies indicate significant changes in neurotrophin levels during ACS, linking them to ischemia, reperfusion injury, inflammation, and myocardial remodeling. There's evidence that elevated or decreased levels of certain neurotrophins can predict short-term and long-term outcomes in patients with ACS. Further research, especially large multicenter studies, is necessary to confirm the value of neurotrophin measurement in ACS as a significant biomarker in clinical practice.
subject: Pregled literature
  topic: section
subject: Array
  topic: keywords
creator: Miodrag Sreckovic
creator: Radiša Vojinović
creator: Davor Kumburović
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-07-07
publication date: 2025-07-07
doi: 10.5937/mckg59-59197

Assessment of indicators of children education in Serbia with implication to the health literacy
type: item
description: Introduction: Access to primary education is the basic right of every child. The aim of the work is to assess the status of the share of children of official primary school age who are not enrolled in school and sex differences, as well as the children enrolled in pre-school education, in Serbia, over a period of 15 years. Method: The research was conducted as an observational epidemiological study. The indicators analysed in this research are the "Share of children of official primary school age who are not enrolled in school" and the indicator "Gross rate of enrolment in preschool education", observation period from 2006 to 2021. Results: The average percentage of male children outside primary school education was 2.18%, while the percentage of female children was 2.14%. The lowest percentage was observed in 2006, and the highest increase in 2010. The linear regression showed a positive trend for both sexes. There was a significant difference in the percentage of boys and girls outside primary school education in Serbia. On average, almost 60% of children were enrolled in preschool institutions in Serbia, and this increase has shown a significant positive trend over observed time. Conclusion: Serbia stands at a crossroads where continued progress in education could lead to major gains in health literacy and equity. Addressing existing disparities with targeted and inclusive educational policies will be essential not only for achieving educational justice but also for building a healthier and more informed society.
subject: Original Scientific Paper
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subject: Array
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creator: Milena Maricic
creator: Verica Trbovic
creator: Katarina Pavlovic Jugovic
creator: Danijela Jezdimirovic
creator: Gordana Antic
creator: Vanja Pazun
creator: Slađana Ilić
creator: Milena Jelić
creator: Goran Stojanovic
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-09-22
publication date: 2025-09-22
doi: 10.5937/mckg59-60139

Impact of anxIety on self-perceIved oral health among medIcal students
type: item
description: Background: Oral health can affect mental health in many ways, and vice versa. Anxiety significantly impact the oral health and can lead to gum disease, cavities, dry mouth and bruxism and can cause bad oral health habits. Aims of our study were to investigate the prevalence of anxiety among medical students and to determinate the impact of anxiety on oral health habits and self-perceived oral health. Methods: This study presents cross-sectional study. It included the medical students from the Faculty of Medical Sciences, University of Kragujevac, Serbia. The Zung Self-Rating Anxiety Scale (SAS) was used to quantify anxiety levels and Oral Health Questionnaire for Adults was used to assess the self-perceived oral health. Data was analysed using the SPSS software, chi-square test was performed to determinate correlation between categorical variables, and Bonferroni analysis was perform to identify the precise significance between groups. Results: The assessment of the self-perceived anxiety showed that 39% of students had symptoms of anxiety. Significant positive correlation was found between anxiety and gender and self-perceived gum condition. Significant negative correlation was found between anxiety and ashamed because of teeth, avoid smiling and using dental floss. The post hoc Bonferroni analysis revealed that women exhibited anxiety more often than men, better gum health was linked to lower anxiety, embarrassment about teeth or avoiding smiling was associated with higher anxiety, and unexpectedly, flossing was more common among anxious participants. Conclusion: The influence of anxiety on oral health is not sufficiently recognized a. We found high prevalence of anxiety among medical students and determined correlation with certain oral health aspects. Medical students are vulnerable group and promotion and preventive programs should be more available.
subject: Original Scientific Paper
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creator: Jovan Rakic
creator: Milos Stepovic
creator: Nikola Jovanovic
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-10-03
publication date: 2025-10-03
doi: 10.5937/mckg59-60963

Effects of bile salts and hymecromone on gallstone recurrence in adult patients after laparoscopic cholecystolithotomy
type: item
description: Given the priority of organ preservation in modern surgery, optimising postoperative treatment, particularly following the removal of gallstones while preserving the gallbladder, is highly relevant. This study aimed to evaluate the effectiveness of comprehensive medical support in restoring gallbladder functionality and preventing the recurrence of gallstone disease (GSD) after organ-preserving cholecystolithotomy. The study was retrospective in design, covering the period from 2018 to 2024, and was conducted at a medical centre in Almaty, Kazakhstan, a country with a high prevalence of GSD. It included 115 patients aged 18 to 65 years who underwent cholecystolithotomy. Of these, 98 patients remained under dynamic observation for a specified follow-up period. Postoperative pharmacotherapy comprised ursodeoxycholic and taurodeoxycholic acids, hymecromone, broad-spectrum antibiotics to prevent infectious complications, analgesics for pain management, antispasmodics to relieve biliary tract spasms, and other medications, with dosages adjusted individually based on the patients’ conditions. To monitor gallbladder status and evaluate treatment effectiveness, ultrasound examinations (US) were performed preoperatively, postoperatively, and periodically during the observation period. The comprehensive assessment also included a general urine analysis conducted before and after surgery. The results of US indicated that complex drug therapy facilitated the normalisation of gallbladder wall size and thickness, as well as improved contractile function. Long-term follow-up revealed that 98.6% of patients retained normal gallbladder contractility, the recurrence rate of cholelithiasis was only 0.07%, and sludge formation was observed in 8.9% of cases. In conclusion, complex pharmacotherapy following cholecystolithotomy with gallbladder preservation is an effective approach for restoring organ function, preventing recurrent stone formation, and enhancing patients’ quality of life.…
subject: Original Scientific Paper
  topic: section
creator: Tursunay Salikhova
creator: Yerkin Kuramyssov
creator: Laura Zhirgalieva
creator: Arsen Salikhov
creator: Yussupzhan Rakhmatullin
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-09-25
publication date: 2025-09-25
doi: 10.5937/mckg59-60230

CALCITONIN NEGATIVE MEDULLARY THYROID CARCINOMA
type: item
description: Medullary thyroid cancer (MTC) is a neuroendocrine neoplasm that arises from parafollicular C cells. Basal and stimulated calcitonin are used in screening, differential diagnosis, assessment of response to treatment and monitoring of MTC. Calcitonin-negative MTC (MTC with normal values of basal and stimulated calcitonin) is extremely rare (49 cases described in the literature). In the absence of appropriate disease predictors, the diagnosis of calcitonin-negative MTC is not easy and is often delayed. A patient with a nodule in the thyroid gland and diskettely elevated calcitonin values is shown. Calcium gluconate stimulation test and carcinoembryonic antigen were normal, and the existence of MTC was ruled out. After a year, the patient notices pain in the lower part of the spinal column. He is referred to rehabilitation treatment, which does not give significant results. Laboratory work-up determines elevated values of parathyroid hormone, scintigraphy shows an enlarged hyperactive lower left parathyroid gland, and thyroidectomy and lower left parathyroidectomy with lymphadenectomy are performed. Pathohistological examination revealed MTC pT1aNxMx. Immunohistochemical analysis was negative for calcitonin and thyroglobulin, positive for chromogranin A and thyroid transcription factor 1 (Thyroid transcription factor-1. Further randomized clinical trials are needed to identify appropriate predictors of calcitonin-negative MTC. Until then, it is necessary to keep in mind the existence of calcitonin-negative MTC that cannot be identified by basal and stimulated calcitonin and carcinoembryonic antigen.
subject: Review
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subject: Array
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creator: Marijana C Jandrić-Kočić
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-06-05
publication date: 2025-06-05
doi: 10.5937/mckg59-50816

PSYCHODERMATOLOGY – FOCUS ON PSYCHIATRIC OUTCOMES OF THERMAL SKIN INJURIES
type: item
description: Psychodermatology represents the discipline that explores the complex interaction between the central nervous system and the skin and offers a lot of confirmations for bidirectional interconnection between the pathological alterations that affect both the skin and nervous system. Psychodermatological disorders can be classified into three principal groups: Psychophysiological disorders, Psychiatric disorders with dermatological symptoms, and Dermatological disorders with psychiatric symptoms, while other entities that appear in clinical practice are classified as Miscellaneous. Thermal skin injuries are classified in the category of dermatitis artefacta. It has been confirmed that burns do not affect somatic health components only, but also have a deep impact on the patient’s mental health and overall quality of life. Severe thermal skin injuries have been shown to also exert a significant systemic response that is finally accompanied by a visible impact on mental health. The major groups of markers that show the common type of alterations that connect cutaneous events (typical for thermal injury) and mental outcomes accompanied by burns are oxidative stress and inflammation markers, neurotransmitters, and neurotrophin system elements. The aim of this literature overview was to summarize some specific clinical entities for psychiatric/dermatological disorders that share the same underlying pathophysiological mechanisms, especially from the rarely evaluated direction (“skin to brain”) – psychiatric outcomes of thermal skin injuries.
subject: Review Paper
  topic: section
subject: Array
  topic: keywords
creator: Marko Simic
creator: Uros Velickovic
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-07-07
publication date: 2025-07-07
doi: 10.5937/mckg59-59185

Kawasaki disease - a single centre experience
type: item
description: Abstract Objective: To compare clinical symptoms, treatment, and outcomes between typical and atypical forms of Kawasaki disease (KD) in patients treated at our institution. Methods: A retrospective observational study was conducted at the Pediatric Clinic, University Clinical Center Niš, reviewing medical records of 17 patients diagnosed with KD between September 2017 and February 2024. Clinical characteristics, laboratory results, treatment regimens, and outcomes were compared between typical (n=12) and atypical KD (n=5) groups. Statistical analysis was performed using the R statistical computing environment. Results: Patients presented with high fever (>38.5 °C) at admission. Diagnosis was delayed in atypical KD cases compared to typical cases (9.6 ± 2.3 days vs. 7.92 ± 2.81 days, respectively). Echocardiographic abnormalities were present in 35% of all cases, including mild left ventricular dysfunction (n=2) and pericardial effusion (n=4). Treatment with intravenous immunoglobulins (IVIg) and aspirin led to significant clinical improvement in most patients. However, corticosteroids were added in 12% (n=2) of cases due to prolonged fever despite initial therapy. One atypical KD patient, diagnosed late, was treated with aspirin alone. Laboratory markers showed notable improvements post-treatment, particularly CRP reduction in typical KD from 77.33 ± 55.92 mg/L to 9.43 ± 7.04 mg/L. Conclusion: Both typical and atypical KD patients showed good short- and medium-term prognoses, with no significant complications noted during follow-up. However, delays in diagnosis, particularly among atypical cases, highlight the need for improved communication across healthcare levels. A larger, multicenter study is recommended to enhance patient management and outcomes. Keywords: vasculitis, pediatric, treatment, laboratory
subject: Professional Paper
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subject: Array
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creator: Nikola Jovanović
creator: Dragana
creator: Karin Vasić
creator: Hristina
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-06-05
publication date: 2025-06-05
doi: 10.5937/mckg59-58563

The Role of the Neutrophil-to-Lymphocyte Ratio in the Development of Heart Failure in Patients with Concomitant Hypertension, Type 2 Diabetes, and Obesity
type: item
description: Objective. Arterial hypertension, type 2 diabetes mellitus (T2DM), and obesity increase cardiovascular risk, including heart failure (HF). The neutrophil-to-lymphocyte ratio (NLR), a systemic inflammation marker, has been linked to adverse cardiovascular outcomes, but its role in HF development remains unclear. This study evaluated NLR as a predictor of HF in these patients. Methods. A total of 293 patients with essential hypertension, T2DM, and obesity were enrolled in a prospective study. They were categorized into two groups: HF group (n=85) and non-HF group (n=208). NLR was calculated from complete blood count results. HF was diagnosed based on the 2023 ESC guidelines and confirmed via biomarkers (NT-proBNP) or echocardiography. Patients were followed for 24 months. Results. Patients who developed HF had significantly higher NLR (3.39 ± 1.23 vs. 2.66 ± 1.14, p<0.001). HF patients also had longer T2DM (12.75 ± 5.86 vs. 10.25 ± 4.39 years, p<0.001) and hypertension durations (18.87 ± 8.54 vs. 16.05 ± 7.14 years, p=0.004). A non-dipper blood pressure profile was more frequent in the HF group (36.5% vs. 20.7%, p=0.005). In multivariate regression, NLR (OR 1.383; 95% CI 1.073–2.222; p=0.037), non-dipper BP profile, and disease duration remained independent HF predictors. Conclusion. NLR is independently associated with HF onset in patients with hypertension, T2DM, and obesity. It may serve as a simple, cost-effective biomarker for HF risk stratification, facilitating early intervention and improved outcomes.
subject: Original Scientific Paper
  topic: section
subject: Array
  topic: keywords
creator: Borys Shelest
creator: Oleksandra Babycheva
creator: Olga Sadovenko
creator: Oleksii Kalmykov
creator: Iulia Rodionova
creator: Nataliia Sukhonos
creator: Yuliia Kovalova
creator: Oleksiy Shelest
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-08-19
publication date: 2025-08-19
doi: 10.5937/mckg59-57351

A brief screening instrument for the early identification of autism spectrum disorders in Serbia: A psychometric study of the Minute for autism (MAUT) instrument
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description: Objective: This study evaluates the psychometric properties of a brief screening tool for autism spectrum disorder (ASD) within a cohort of children with neurodevelopmental disabilities and typically developing children. Methods: The study involved 306 children (208 boys, representing 68%; mean age 44.6 ± 13.6 months), with data collected from both parents and evaluators (including child psychiatrists, special education teachers, speech therapists, pedagogues, and preschool teachers). The prototype instrument, Minute for Autism (MAUT), consisting of 15 items assessing key ASD symptoms, was tested. Results: Analysis identified a single factor represented by 7 items in parental assessments (accounting for 53.3% of variance) and 10 items in evaluator assessments (accounting for 53.6% of variance), with primary indicators focusing on measures of social engagement. Four dominant items emerged: "the child looks at you when you speak or play with them," "the child addresses others," "the child talks," and "the child brings objects/toys to show you." These items demonstrated a sensitivity of 72.9% for parental assessments and 84.8% for evaluator assessments. The specificity for detecting ASD, as opposed to typical development, was high (94.1% for parents and 100% for evaluators), although it was lower for differentiating ASD from complex neurodevelopmental disorders (70.8% for parents and 46.2% for evaluators). Conclusion: The findings suggest that an instrument featuring only four items related to social engagement could be sufficiently effective for rapid and early ASD screening. Evaluators appeared more sensitive to ASD identification than parents, whereas parents were more accurate in distinguishing ASD from other disorders. The primary challenge remains in differentiating ASD from other neurodevelopmental disorders, where the instrument may produce false positives. Future studies should assess the instrument's efficacy in populations of at-risk children.
subject: Original Scientific Paper
  topic: section
creator: Dejan Stevanović
creator: Zoran Kovačić
creator: Marija Cvijetić Vukčević
creator: Aleksa Milević
creator: Slavica Cvetković Brkić
creator: Andrijana Dodić
creator: Jelena Mrvić
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-06-05
publication date: 2025-06-05
doi: 10.5937/mckg59-57347

The role of tryptase in the human body: From normal to pathology
type: item
description: The purpose of the work was to investigate the effect of the tryptase enzyme on the functioning of the human body in normal and pathological conditions. A search for relevant studies in the PubMed, Scopus, GoogleScholar, ResearchGate and Web of Science databases, presented for 2014-2024, was performed. The study revealed that tryptase is an enzyme of mast cells and a marker for assessing their activity. Tryptase is involved in the regulation of the growth and development of mesenchymal cells, fibroblasts and endothelial cells, regulation of blood clotting, metabolic processes of connective tissue, and affects the contractility of smooth muscle cells. Under pathological conditions, impaired tryptase metabolism leads to excessive fibrosis, development of keloid scars, narrowing of kidney vessels, transplant rejection, development of inflammatory bowel disease, arthritis, psoriasis, atopic and contact dermatitis. The normal level of serum tryptase is 5 ng/ml. The threshold value of the enzyme is 11.4 ng/ml. Increased levels of this enzyme are found in 4-6% of the population. An increase in serum tryptase levels is diagnosed in hereditary pathologies (hereditary alpha-tryptasemia) and acquired diseases (mastocytosis, mast cell activation syndromes, monoclonal mast cell activation syndrome, anaphylaxis, chronic kidney disease). The clinical picture is characterized by lesions of the cardiovascular, gastrointestinal, respiratory, excretory, and integumentary systems and the development of anaphylaxis. The pathogenesis of the diseases is still under investigation, so the treatment of the described pathologies is mainly symptomatic. It is concluded that tryptase is the main biomarker of mast cell function, and that impaired metabolism of this enzyme leads to a number of severe, life-threatening pathologies.
subject: Review Paper
  topic: section
creator: Maria Zofia Lisiecka
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-06-05
publication date: 2025-06-05
doi: 10.5937/mckg59-55869

Spontaneous subcapsular renal hematoma as a cause of acute abdominal pain - a case report
type: item
description: <!-- [if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves/> <w:TrackFormatting/> <w:PunctuationKerning/> <w:ValidateAgainstSchemas/> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF/> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>ZH-CN</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables/> <w:SnapToGridInCell/> <w:WrapTextWithPunct/> <w:UseAsianBreakRules/> <w:DontGrowAutofit/> <w:SplitPgBreakAndParaMark/> <w:EnableOpenTypeKerning/> <w:DontFlipMirrorIndents/> <w:OverrideTableStyleHps/> </w:Compatibility> <w:DoNotOptimizeForBrowser/> <m:mathPr> <m:mathFont m:val="Cambria Math"/> <m:brkBin m:val="before"/> <m:brkBinSub m:val="--"/> <m:smallFrac m:val="off"/> <m:dispDef/> <m:lMargin m:val="0"/> <m:rMargin m:val="0"/> <m:defJc m:val="centerGroup"/> <m:wrapIndent m:val="1440"/> <m:intLim m:val="subSup"/> <m:naryLim m:val="undOvr"/> </m:mathPr></w:WordDocument> </xml><![endif]--><!-- [if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="false" DefSemiHidden="false" DefQFormat="false" DefPriority="99" LatentStyleCount="376"> <w:LsdException Locked="false" Priority="0" QFormat="true" Name="Normal"/> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 1"/> <w:LsdException Locked="false" Priority="9" SemiHidden="true" UnhideWhenUsed="true" QFormat="true" Name="heading 2"/> <w:LsdException Locked="false" Priority="9" SemiHidden="true" UnhideWhenUsed="true" QFormat="true" Name="heading 3"/> <w:LsdException Locked="false" Priority="9" SemiHidden="true" UnhideWhenUsed="true" QFormat="true" Name="heading 4"/> <w:LsdException Locked="false" Priority="9" SemiHidden="true" UnhideWhenUsed="true" QFormat="true" Name="heading 5"/> <w:LsdException Locked="false" Priority="9" SemiHidden="true" Unhid…
subject: Review
  topic: section
subject: Array
  topic: keywords
creator: Nikola Krunić
creator: Pavle Petković
creator: Filip Jovanović
creator: Tode Dragičević
creator: Milica Jelić
creator: Slađana Ilić
creator: Radiša Vojinović
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-06-05
publication date: 2025-06-05
doi: 10.5937/mckg59-58273

WORK STRESS, BURN-OUT SYNDROME AND PSYCHOLOGICAL CONSEQUENCES
type: item
description: Cilj: Cilj ovog istraživanja je bio sagledati značaj i posledice stresa na radnom mestu. Metode: Učinjena je deskriptivna opservaciona studija primenom strukturisanog upitnika (ankete) na uzorku radon aktivne populacije. Istraživanje je sprovedeno na teritoriji Beograda, Srbija, u vremenskom period koji je obuhvatio januar i februar 2023.godine, sa ukupnim brojem ispitanika od 50. Rezultati: Pokazano je da je u ukupnom uzorku najveći broj ispitanika bio ženskog pola i srednje stručne spreme. Većina nije bila zadovoljna uslovima rada i zaradom. Dalje, većina ispitanika je imala neki od somatskih simptoma kao posledicu permanentne izloženosti stresu. Najčešći modalitet za prevladavanje stresa je bio čitanje, potom sledi fizička aktivnost i šoping. Zaključak: Naše istraživanje je pokazalo da hronični stress neminovno dovodi do razvoja somatskih i psiholoških posledica što se apsolutno poklapa sa istraživanjima rađenim u svetu do sada. Veliki broj radon aktivne populacije izgara, a ako ovo traje kroz vreme, dovodi do sindroma izgaranja koji sa sobom nosi hroničnu depresiju kao deterirativnu i po celokupnu ličnost pojedinca devastirajuću konsekvencu. Ključne reči: sindrom izgaranja, stress na radu, hronična depresija
subject: Original Scientific Paper
  topic: section
creator: Stevan Barać
creator: Jelena Miletić
creator: Milica Pantić
creator: Miona Glišić
creator: Nemanja Murić
creator: Ermin Fetahović
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-06-05
publication date: 2025-06-05
doi: 10.5937/mckg59-57054

THE IMPAKT OF DOMINANT CENTRAL NERVOUS SYSTEM INJURIES ON THE SURVIVAL OF TRAFFIC ACCIDENT VITIMS IN MONTENEGRO
type: item
description: <!-- [if gte mso 9]><xml> <o:OfficeDocumentSettings> <o:AllowPNG/> </o:OfficeDocumentSettings> </xml><![endif]--><!-- [if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves/> <w:TrackFormatting/> <w:HyphenationZone>21</w:HyphenationZone> <w:PunctuationKerning/> <w:ValidateAgainstSchemas/> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF/> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables/> <w:SnapToGridInCell/> <w:WrapTextWithPunct/> <w:UseAsianBreakRules/> <w:DontGrowAutofit/> <w:SplitPgBreakAndParaMark/> <w:EnableOpenTypeKerning/> <w:DontFlipMirrorIndents/> <w:OverrideTableStyleHps/> </w:Compatibility> <m:mathPr> <m:mathFont m:val="Cambria Math"/> <m:brkBin m:val="before"/> <m:brkBinSub m:val="--"/> <m:smallFrac m:val="off"/> <m:dispDef/> <m:lMargin m:val="0"/> <m:rMargin m:val="0"/> <m:defJc m:val="centerGroup"/> <m:wrapIndent m:val="1440"/> <m:intLim m:val="subSup"/> <m:naryLim m:val="undOvr"/> </m:mathPr></w:WordDocument> </xml><![endif]--><!-- [if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="false" DefSemiHidden="false" DefQFormat="false" DefPriority="99" LatentStyleCount="371"> <w:LsdException Locked="false" Priority="0" QFormat="true" Name="Normal"/> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 1"/> <w:LsdException Locked="false" Priority="9" SemiHidden="true" UnhideWhenUsed="true" QFormat="true" Name="heading 2"/> <w:LsdException Locked="false" Priority="9" SemiHidden="true" UnhideWhenUsed="true" QFormat="true" Name="heading 3"/> <w:LsdException Locked="false" Priority="9" SemiHidden="true" UnhideWhenUsed="true" QFormat="true" Name="heading 4"/> <w:LsdException Locked="false" Priority="9" SemiHidden="tr…
subject: Original Scientific Paper
  topic: section
subject: Array
  topic: keywords
creator: Damir Pelicic
creator: Branko Ristic
creator: Tanja Boljevic
creator: Svetlana Radevic
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-06-12
publication date: 2025-06-12
doi: 10.5937/mckg59-56488

Can leukotriene receptors inhibitors preserve cognitive functions in asthma patients?
type: item
description: Background: Recent research suggests that neuroinflammation may play a crucial role in age-related cognitive dysfunction. Studies have investigated the impact of leukotriene receptor inhibitors (LTR) antagonist montelukast, a medication commonly used to treat allergies and asthma, on the risk of developing dementia. The aim of this study was to compare cognitive functions in asthmatic patients who used and who don’t use montelukast and healthy controls. Method: In this study 50 asthmatic patients (age 67.34±6.44) (20 montelukast users and 30 montelukast nonusers) were matched with 50 healthy controls (age 68.08±5.95). Each participant was assessed with the Mini Mental State Examination (MMSE) and the Montreal Cognitive Test (MoCA). Memory coefficients (verbal, visual, general, delayed memory, and attention and concentration) were measured by Wechsler Memory Scale-Revised (WMS-R). Results: Orientation as MoCA subdomain was worse in patients with asthma compared to the control group (p=0.048). Asthmatic patients treated with montelukast had a significantly higher MoCA score (p=0.033) (dominantly due to delayed recall) (p=0.044) than patients without montelukast treatment. People with asthma on montelukast therapy showed statistically significantly better results on the MoCA test (p=0.037) compared to the control group (dominantly due to attention (p=0.032) and delayed recall (p=0.021)). Conclusion: Montelukast group compared to montelukast nonusers had better results on MoCA (dominantly due to delayed recall). Studies with a larger number of participants are needed to confirm the effect of montelukast on the cognitive status of the elderly.
subject: Original Scientific Paper
  topic: section
subject: Array
  topic: keywords
creator: Dejan Aleksic
creator: Snezana Lazarevic
creator: Romana Susa
creator: Zorica Lazic
creator: Ivan Cekerevac
creator: Gordana Toncev
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-06-05
publication date: 2025-06-05
doi: 10.5937/mckg59-53102

SUCCESSFUL CARDIOPULMONARY RESUSCITATION USING A DEFIBRILLATOR PLACED IN A PUBLIC PLACE - CASE REPORT
type: item
description: SAŽETAK: Cilj: Rana defibrilacija ritmova koji se mogu defibrilirati povezana je sa poboljšanim preživljavanjem, ali je osiguravanje pravovremenog pristupa defibrilatorima predstavljalo značajan izazov. Do danas, razvoj javnih programa defibrilacije, koji uključuje postavljanje automatizovanih eksternih defibrilatora u javni prostor, bio je glavna strategija za rešavanje ovog izazova. Metode: Prikazan je slučaj 47-godišnjeg muškarca sa akutnim infarktom miokarda i VF. Analizirani su podaci ambulantnog protokola, anamneza i otpusne liste iz hitne pomoći, jedinice intenzivne nege. Rezultati: Pacijent je osjetio mučninu, vrtoglavicu, znojenje. Kćerka ga pronalazi na podu bez svijesti, ne diše. Otpočeo reanimaciji, i pozvana je hitna pomoć. Policija dolazi prva i upotrebljava AED defibrilator. Na monitoru defibrilatora registrje se VF i donijeta je odluka o primeni DC šoka. AED defibrilator isporučuje 5 šokova. Nakon DC šoka, pacijent počinje da diše. Hitna dolazi nakon 6 minuta i nastavlja se sa reanimacijom. Pacijent je prevezen u Urgentni centar. EKG tokom transporta pokazao je sinusni ritam od 100/min sa elevacijom ST segmenta u V1-V5 i depresijom ST segmenta V6. Vitalni parametri tokom transporta (CCS 11, SpO2 90% , krvni pritisak je nemerljiv) Pacijent je intubiran. Terapija Amoidaron amp 150mg/3m: 300mg IV Fentamed amp 0,5/10ml: 0,3 mgIV, Biropehen amp.0,5mg/5ml :0,4mg IV, Rocuroniumbromid kabl.50mg/5ml: 80mg/5ml: 80mg/1mg 0,3 mg IV U Hitnoj pomoći imao je tri epizode ventrikularne tahikardije. Nakon uspješne kardioverzije, pacijent je imao stabilan ritam. Pacijent je pripremljen za PCI, stent na LAD. Nakon katakterizacije, implantacije STENT i stabilizacije, primijenjena je terapijska hipotermija sa Hladnim Ringer laktatom 500 ml na 4°C intravenski. Temperatura je smanjena na 33°C i održavana je 24 sata. Zaključak: Što se prije započne CPR, to je bolji ishod. U prve 3 minute šansa za povratak spontane cirkulacije je 75%. Nakon 4 minute je 40%. Nakon 5 minuta šan…
subject: Review
  topic: section
subject: Array
  topic: keywords
creator: Vuk Nikovic
creator: Kenan Erović
creator: Anton Laggner
creator: Dušica Gujaničić
creator: Vladimir Gajić
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-02-26
publication date: 2025-02-26
doi: 10.5937/mckg58-51154

PREHOSPITAL CARE AND TREATMENT OF INJURED IN TRAFFIC ACCIDENTS
type: item
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subject: Review Paper
  topic: section
subject: Array
  topic: keywords
creator: Damir Pelicic
creator: Branko Risti'
creator: Svetlana Radevic
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-02-26
publication date: 2025-02-26
doi: 10.5937/mckg58-52538

RESILIENCE AND HEALTHY LIFESTYLES IN THE POPULATION OF NURSES, NURSING STUDENTS AND ADMINISTRATIVE WORKERS
type: item
description: Aim: The aim of this study is to determine whether resilience is associated with healthy lifestyles, defines as physical activity, dietary habits and proper sleep, in a population of nurses, students and administrative workers. Materials and methods: The study included a total of 290 respondents: 149 nurses, 71 clerks and 70 nursing students, from six different cities in the territory of Serbia, during the year 2022. To assess resilience, we used Brief Resilience Scale (BRS). In order to examine the influence of healthy lifestyles, we asked respondents to fill out a questionnaire which included general questionnaire about socio-demographic and lifestyle characteristics, International Physical Activity Questionnaire (IPAQ) and Mediterranean Diet Adherence Screener (MEDAS). Results: People who predominantly use olive oil in their diet as a main culinary fat are more resilient that those who do not use it (r = 0.024). There is no statistically significant difference between resilience and parameters of physical activity. Resilience is associated with sleep problems, optimism and place of living. Conclusion: The results of our study represent an important starting point for establishing strategies for building resilience, especially in the population of healthcare workers, considering that the majority of our sample consists of nurses. Such results take on a new dimension in times of major social global changes (recent coronavirus pandemic, wars), which result in the overloading of national health systems.
subject: Original Scientific Paper
  topic: section
subject: Array
  topic: keywords
creator: Milena Despotović
creator: Dragana Ignjatović-Ristić
creator: Dragic Bankovic
creator: Mile Despotovic
creator: Milena Zlatanovic
creator: Jelena Jovic
rights: Copyright (c) 2025 Medicinski časopis
date: 2025-03-16
publication date: 2025-03-16
doi: 10.5937/mckg58-56384