Kako citirati
Sažetak
Background: Conclusions on susceptibility of MMP3 -1612 5A/6A to morbid risk of coronary artery disease (CAD) are controversial. This meta-analysis aims to obtain the accurate relationship between them.
Methods: Relevant literatures on susceptibility of MMP3 -1612 5A/6A to morbid risk of CAD published before July 2019 were searched in PubMed, Web of Science, Cochrane Library, CNKI, VIP and Wanfang. Data were extracted from eligible literatures and analyzed by RevMan5.3 and STATA12.0 for calculating OR and corresponding 95% CI. Study selection: A total of 18 literatures reporting MMP3 -1612 5A/6A and CAD were enrolled. Data extraction was conducted by two researches independently. Any disagreement was solved by the third research.
Results: In recessive model (OR=1.3, 95%CI=1.2-1.64, P=0.03) and over-dominant model (OR=1.50, 95%CI=1.14-1.97, P=0.002), MMP3 -1612 5A/6A was correlated to susceptibility of CAD. Subgroup analysis uncovered that in different genetic models, MMP3 -1612 5A/6A was correlated to susceptibility of CAD in East Asian population (mainly Chinese population).
Conclusions: MMP3 -1612 5A/6A is closely linked to morbid risk of CAD. Gene-environment interaction is the research focus in future analyses.
Ključne reči
CAD
polymorphism
The published articles will be distributed under the Creative Commons Attribution 4.0 International License (CC BY). It is allowed to copy and redistribute the material in any medium or format, and remix, transform, and build upon it for any purpose, even commercially, as long as appropriate credit is given to the original author(s), a link to the license is provided and it is indicated if changes were made. Users are required to provide full bibliographic description of the original publication (authors, article title, journal title, volume, issue, pages), as well as its DOI code. In electronic publishing, users are also required to link the content with both the original article published in Journal of Medical Biochemistry and the licence used.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.